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Doctor's Best MSM with OptiMSM, Joint Support, Immune System, Antioxidant and Protein-Building Role, Non-GMO, Gluten Free, 1000 mg, 180 Caps (DRB-00064)
Purchase options and add-ons
Brand | Doctor's BEST |
Flavor | Unflavored |
Primary Supplement Type | mineral |
Unit Count | 180 Count |
Item Form | Capsule |
Item Weight | 10.24 ounces |
Item Dimensions LxWxH | 3.13 x 3.13 x 5.19 inches |
Special Ingredients | Methylsulfonylmethane |
Diet Type | Gluten Free |
Product Benefits | Bone & Joint Support |
About this item
- DOCTOR’S BEST MSM FEATURES OPTIMSM: with OptiMSM a high quality purified MSM (methylsulfonylmethane) backed by numerous clinical studies for safety and efficacy. MSM is a natural sulfur compound that helps support the formation of healthy connective tissues. It also helps support overall joint mobility, and a normal range of motion.
- BENEFITS TO JOINTS: MSM is a natural sulfur that helps form the antioxidants N-acetylcysteine and glutathione and serves as a key structural nutrient in healthy joints. Improves joint function and helps protect cartilage, mobility, reduces joint pain, increases range of motion.
- IMMUNE SUPPORT: MSM provides support for immune function, and for the body’s antioxidant and overall protective capacities resulting in a stronger immune response.
- NATURE’S BEAUTY MINERAL: MSM provides sulfur and is often called “nature’s beauty mineral”. Sulfur restores collagen production that supports healthy skin and is a building block of keratin, an essential protein for improving skin, hair and nails.
- CLINICAL STUDIES: Sulfur continues to be an important dietary nutrient to support healthy aging. With its regulation of glutathione and other ways in the body, MSM can help support healthy skin, joint mobility, cartilage, and the antioxidant response.
- During the summer months products may arrive warm but Amazon stores and ships products in accordance with manufacturers' recommendations, when provided.
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From the manufacturer
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Doctor’s Best MSM with OptiMSM a high quality purified MSM (methylsulfonylmethane) backed by numerous clinical studies for safety and efficacy.*
MSM IS a natural sulfur compound that helps support the formation of healthy connective tissues. It also helps support overall joint mobility, and a normal range of motion.* It also may help reduce oxidative damage to support a immune system.
MSM provides the sulfur reputable for being nature’s ‘beauty mineral’. Sulfur is a key component of collagen that supports the skin’s structural framework and is also a building block of keratin, a structural constituent of hair and nails.*
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What are the benefits of MSM?
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Why take MSM?
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How does it work?
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Promotes joint comfort and mobility.*
In a double blind, placebo-controlled trial, 50 men and women were randomized to receive either 3,375 mg (3.375 grams) of MSM or a placebo daily for 12 weeks.7 Participants were instructed to take the tablets (each was 1.125 grams) in three doses per day with food, and to avoid taking the tablets before bed. Several validated and reliable scoring methods were used to measure joint function and comfort during the study. Compared with placebo, MSM was shown to significantly promote joint function and comfort, without side effects.
A larger dose was used in a randomized, double blind, placebo-controlled trial of 50 men and women (ages 40–76).8 Participants were randomized into two groups to receive either placebo capsules or OptiMSM in 1 gram capsules for 12 weeks. They were instructed to ramp up to the eventual dose of 6 grams per day by starting with two doses of 2 grams per day for 3 days, followed by an increase to 4 grams per day for the next 4 days. At the beginning of the second week, the dose was raised to 3 grams twice daily. Participants were instructed to take the MSM with food, and to avoid taking it at bedtime. Knee joint function and comfort were measured by standardized (reliable and valid) questionnaires. After 12 weeks, physical function and knee joint comfort were shown to be superior in the MSM group when compared to placebo.
In a more complex double blind study, MSM was tested versus (a) a placebo, (b) glucosamine, and (c) a combination of MSM with glucosamine, in 118 men and women (ages 40–70).9 Participants were randomized into four groups to receive either a placebo, MSM alone (500 mg three times daily), glucosamine alone (500 mg three times daily), or MSM + glucosamine (500 mg each, three times daily). Using a number of analytical tools that measured joint functionality, comfort, and quality of life related to joint health, the researchers found that the MSM and glucosamine groups experienced significant support for joint health, whereas the placebo group experienced no such benefits. Additionally, the combination of MSM + glucosamine was significantly better at promoting joint comfort and functional ability than either taken alone.
MSM could serve as a source of sulfur to support the maintenance and formation of cartilage, thereby supporting knee joint health.10 Its two methyl groups could be valuable to its actions, being necessary for tissue repair and maintenance. Its molecular structure suggests it could also have redox (electronic catalytic) properties that would facilitate antioxidant or other human benefits.
Enhances antioxidant defenses.*
Supports healthy immune response.*
Oxidative stress is a term used to describe negative imbalance between production of reactive oxygen species (ROS) and the body’s antioxidant capacities. Strenuous exercise have the potential to create an uptick of ROS, and subsequently oxidative stress.11 Human and animal studies suggest that taking MSM prior to exercise may help to ease oxidative stress, especially in individuals not accustomed to the stress of exercise.12, 13.
In an exploratory trial of eight healthy men accustomed to a moderate amount of exercise (no more than 2.5 hours per week), the effect of MSM on antioxidant capacity after exercise was investigated. Half of the participants were given 1.5 grams of OptiMSM per day, and the other half 3.0 grams per day. Both groups took the MSM for 30 days, and were instructed to split their daily dose in order to take half of it in the morning and half in the evening. On two exercise test days (before and after 28 days of MSM consumption), participants took their morning MSM dose immediately prior to eating a standardized breakfast, then performed 18 sets of a standardized exercise. A statistically significant increase in blood antioxidant capacity following exercise was reported in the group taking 3 grams MSM daily, as measured by the well-accepted Trolox Equivalent Antioxidant Capacity assay.12.
MSM has been suggested to support healthy immune function through antioxidant actions. Neutrophils, the most abundant white blood cells in the body, routinely release free radicals crucial to their immune activities; this can be a double-edged sword, as excessive free radical generation contributes to oxidative stress. Laboratory research suggests MSM can help regulate free radical production by neutrophils.14 In mice macrophage (immune) cells, MSM was shown to down-regulate overactive immune factors without being toxic to the cells.15 In a mouse model examining joint health, MSM dissolved in the drinking water influenced immune function in a way that significantly supported joint structure and function when compared to mice in a control group.16.
MSM’s benefits for human immune function were studied in an open-label clinical trial. A total 50 men and women were given OptiMSM, 2.6 grams per day for 30 days.17 The MSM was given as four 650 mg capsules-two in the morning and two in the afternoon-each day. Immune function was measured by questionnaire, which included three subsections of questions about upper respiratory health (the head, eyes, nose, and throat), lower respiratory health (the lungs and chest), and energy level. The data suggested MSM produced clinically significant support for the upper respiratory system after one week, the lower respiratory system after three weeks, and enhanced energy levels after two weeks. These benefits continued into the fourth and final week of the study. A subset of 16 participants who experienced the least benefit from the MSM were selected to continue taking OptiMSM for an additional 14 days, but at the higher dose of 5.2 grams per day. These individuals then reported experiencing significantly enhanced energy levels and superior overall respiratory scores.
While new research is exploring the potential of methylsulfonylmethane in promoting the maintenance of GI health18 and bone health,19 the current clinical evidence shows MSM provides meaningful support for the joints, for immune function, and for the body’s antioxidant and overall protective capacities. MSM is proven very safe to take, very well tolerated, and effective at intakes as high as 6000 mg (6 grams) per day.
Scientific References:
1. Monograph. Altern Med Rev 2003;8:438-41.
2. Parcell S. Altern Med Rev 2002;7:22-44.
3. Lovelock JE, Magga RJ. Nature 1972;237:452-453.
4. Jacob SW, Herschler R. Annals of the NY Acad Sci 1983;411:xiii-xvii.
5. Pearson TW, Dawson HJ, Lackey HB. J Agric Food Chem 1981;29:1089-91.
6. Silva Ferreira AC, Rodrigues P, Hogg T, Guedes De Pinho P. J Agric Food Chem 2003;51:727-32.
7. Debbi EM, Agar G, Fichman G, others. BMC Complement Altern Med 2011;11:50.
8. Kim LS, Axelrod LJ, Howard P, others. Osteoarthritis Cartilage 2006;14:286-94.
9. Usha PR, Naidu MU. Clin Drug Investig 2004;24:353-63.
10. Ezaki J, Hashimoto M, Hosokawa Y, Ishimi Y. J Bone Miner Metab 2013;31:16-25.
11. Fisher-Wellman K, Bloomer RJ. Dyn Med 2009;8:1.
12. Kalman DS, Feldman S, Scheinberg AR, others. J Int Soc Sports Nutr 2012;9:46.
13. Maranon G, Munoz-Escassi B, Manley W, others. Acta Vet Scand 2008;50:45.
14. Beilke MA, Collins-Lech C, Sohnle PG. J Lab Clin Med 1987;110:91-6.
15. Kim YH, Kim DH, Lim H, others. Biol Pharm Bull 2009;32:651-6.
16. Hasegawa T, Ueno S, Kumamoto S, Yoshikai Y. Jpn Pharmacol Ther 2004;32.
17. Barrager E, Veltmann JR, Jr., Schauss AG, Schiller RN. J Altern Complement Med 2002;8:167-73.
18. Amirshahrokhi K, Bohlooli S, Chinifroush MM. Toxicol Appl Pharmacol 2011;253:197-202.
19. Joung YH, Lim EJ, Darvin P, others. PLoS One 2012;7:e47477.
Product Description
Best MSM supplies highly purified MSM (methylsulfonylmethane), a compound notable for its methyl groups (required for numerous metabolic functions) and the conditionally essential mineral sulfur, which is a crucial component of powerful antioxidants such as N-acetylcysteine and glutathione. Although MSM occurs naturally in some foods and in the human body at low concentrations, a significant amount of MSM is lost during the heating and processing of foods.
Product details
- Is Discontinued By Manufacturer : No
- Product Dimensions : 3.13 x 3.13 x 5.19 inches; 10.24 ounces
- Item model number : DRB-00064
- Date First Available : October 2, 2001
- Manufacturer : Doctor’s Best, Inc
- ASIN : B000BD4DI6
- Country of Origin : USA
- Best Sellers Rank: #11,383 in Health & Household (See Top 100 in Health & Household)
- #6 in MSM Nutritional Supplements
- #1,501 in Sales & Deals
- Customer Reviews:
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This Item Doctor's Best MSM with OptiMSM, Joint Support, Immune System, Antioxidant and Protein-Building Role, Non-GMO, Gluten Free, 1000 mg, 180 Caps (DRB-00064) | Recommendations | dummy | dummy | dummy | dummy | |
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Price | $13.28$13.28 | -15% $13.73$13.73 List: $16.15 | $22.99$22.99 | -19% $16.99$16.99 List: $20.95 | $49.87$49.87 | $17.95$17.95 |
Price Per Unit | $0.07 / Count | $0.05 / Count | $0.08 / Count | $0.08 / Count | $0.17 / Count | $0.07 / Count |
Delivery | Get it as soon as Sunday, Mar 31 | Get it as soon as Sunday, Mar 31 | Get it as soon as Sunday, Mar 31 | Get it as soon as Sunday, Mar 31 | — | Get it as soon as Sunday, Mar 31 |
Customer Ratings | ||||||
Easy to swallow | 4.3 | 4.6 | 3.1 | 4.1 | 4.4 | 3.2 |
Pain relief | 4.2 | 4.5 | 3.8 | 4.5 | — | 3.5 |
Flavor | — | 4.5 | 4.6 | 4.0 | — | 3.5 |
Range of motion | 4.2 | — | 2.3 | 4.1 | — | — |
Sold By | Amazon.com | Carlyle | Carlyle | Amazon.com | Swanson Health Products | eSupplements |
keyword type | msm-nutritional-supplements | msm-nutritional-supplements | msm-nutritional-supplements | msm-nutritional-supplements | coenzyme-q10-nutritional-supplements | multiple-vitamin-mineral-combinations |
form | Capsule | Capsule | Caplet | Capsule | Softgel | Tablet |
size | 180C | 250 Count (Pack of 1) | 300 Count (Pack of 1) | 200 Count (Pack of 1) | 100 Count (Pack of 3) | 240 Count (Pack of 1) |
weight | 0.64 pounds | 7.42 ounces | 0.69 kilograms | 0.29 kilograms | 0.18 pounds | 0.41 kilograms |
age range | Adult | Adult | Adult | Adult | Adult | Adult |
product benefit | Bone & Joint Support | — | — | Antioxidant | Antioxidant | — |
serving suggestion | 3 capsules | 2 capsule | 2 caplets | 1 capsule | One Softgel | 2 tablets daily with water |
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Doctor’s Best. More than just a name
Doctor’s Best, Inc
Important information
Safety Information
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.This product is labelled to United States standards and may differ from similar products sold elsewhere in its ingredients, labeling and allergen warnings
Ingredients
Methylsulfonylmethane 1 gram (1000 mg) , Gelatin (capsule)
Directions
Take 1 capsule twice daily, with or without food, or as recommended by a nutritionally-informed physician.
Legal Disclaimer
These statements have not been evaluated by the Food & Drug Administration. This products is not intended to diagnose, cure, mitigate, treat, or prevent any disease.
Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.
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Customer reviews
Customer Reviews, including Product Star Ratings help customers to learn more about the product and decide whether it is the right product for them.
To calculate the overall star rating and percentage breakdown by star, we don’t use a simple average. Instead, our system considers things like how recent a review is and if the reviewer bought the item on Amazon. It also analyzed reviews to verify trustworthiness.
Learn more how customers reviews work on AmazonCustomers say
Customers like the quality, side effects, ease of swallowing, pain relief, and effect on skin and hair of the nutritional supplement. For example, they mention it's a great product, helps you detox your body from heavy metals, and that it'll improve your skin, hair, and nails.
AI-generated from the text of customer reviews
Customers have good things to say about the pain relief provided by the MSM supplement. They say, for example, it helps to reduce knee and lower back pain, cramps, and muscle pulls. Customers also say it's effective for polymyalgia rheumatica pain and stiffness, and helps to relieve chronic pain. They also say that it helps strengthen the blood vessels and rid the body of toxins. Customers say it completely cures their trigger fingers.
"...have noticed happening with me: Within the first week I noticed a lift in my mood. I also noticed that I began sleeping better at night...." Read more
"...My nails and hair are growing stronger, faster...." Read more
"...My hair is also growing faster - noticeably...." Read more
"...I have scoliosis in mid back and sit/work all day. It keeps the pain away. Powdered capsules easy to swallow." Read more
Customers are satisfied with the quality of the msm supplement. They mention it's a great product, high quality, and pure. Some say that the product has few side effects and is well tolerated.
"...A very enlightening and promising read.I did a little research on the internet to find a quality MSM product...." Read more
"...I sleep so much better. It is pure MSM and I can definitely tell the difference between this and other brands...." Read more
"...Great product!" Read more
"I like the fact that this is pure MSM, with no fillers or flow agents.I also like the fact that the capsule is gelatin...." Read more
Customers like the performance of the nutritional supplement. For example, they say it works well, has amazing results, and starts working almost immediately. Some mention that it helps tremendously and that it works at the cellular level.
"...To find that MSM is working at the cellular level is huge to me. I have learned that taking supplements, herbs, using essential oils, etc...." Read more
"...My neck pops with every breath I take. These have helped tremendously by giving me the ability to turn my head while driving and I no longer wake up..." Read more
"...took the MSM I felt like I had taken a pain medication - I could actually feel it working!..." Read more
"Value is great and seems to work!" Read more
Customers find the nutritional supplement easy to swallow and easy on their budget. They say it provides good value and quality for money. Customers also mention that the amount of caplets and the price drew them to buy this brand.
"...Doctor's Best turned up in the top 2 products. Turns out it is reasonably priced. Yea! I have been taking this product for a month now...." Read more
"...It comes at a great price for the amount you receive. I have more energy...." Read more
"Best pricing for a quantity of MSM. Doctor's Best does not subscribe to third party verification for their products as far as I can tell...." Read more
"Value is great and seems to work!" Read more
Customers say the nutritional supplement improves their skin, hair, and nails. They say it helps to maintain a smoother complexion, looks more plump, and youthful, and is amazing for hair and skin. Customers also experience improved joint health and skin, all without any unwanted side effects. They also mention that the product helps clear their acne up.
"...also noticed (and other people have commented) that my skin looks more plump and youthful. My nails and hair are growing stronger, faster...." Read more
"...I've experienced improved joint health and skin, all without any unwanted side effects. A win-win for those looking for natural remedies." Read more
"The supplement is made for "Joint Support, Immune System, & Antioxidant"...." Read more
"MSM is great for releasing toxins, which helps with allergies, joint pain, skin and hair health. I've been using this for years...." Read more
Customers find the capsules easy to swallow. They also say the pills are easy to use and have experienced no side effects.
"...It keeps the pain away. Powdered capsules easy to swallow." Read more
"I’m on bottle two with my family! They are easy to take and are tasteless! Love the fact they have no smell!" Read more
"Easy to take." Read more
"...Easy to swallow and your joints an body will thank you for it." Read more
Customers like the side effects of the nutritional supplement. They say it helps detox your body from heavy metals, provides sulfur which plays a critical role in detoxification, and helps with allergies, joint pain, and skin. Customers also say it's an antioxidant and doesn't cause weight gain.
"I've been taking MSM supplements, and the best part is they didn't cause any weight gain!..." Read more
"The supplement is made for "Joint Support, Immune System, & Antioxidant"...." Read more
"...However, day 3 was the beginning of multiple undesired side effects including most notably headaches & fatigue...." Read more
"MSM is great for releasing toxins, which helps with allergies, joint pain, skin and hair health. I've been using this for years...." Read more
Customers like the size of the nutritional supplement. They say it's fairly compact, making it easy to swallow. Some customers also mention that the capsules are very large.
"...It's now been 3 months and my hair feels BIG - and I've never had big hair, ever...." Read more
"...These are very large capsules like most in this category but 3 per day?..." Read more
"When capsule power is poured into a glass of water there are various sized white balls which do not dissolve...." Read more
"...This particular product is in smaller size capsule so it is easier to swallow than other brands." Read more
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Top reviews
Top reviews from the United States
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I did a little research on the internet to find a quality MSM product. Doctor's Best turned up in the top 2 products. Turns out it is reasonably priced. Yea! I have been taking this product for a month now. Here is what I have noticed happening with me: Within the first week I noticed a lift in my mood. I also noticed that I began sleeping better at night. As I continue to take it I have noticed I am beginning to feel more energetic and better in my joints. I wasn't looking for anything specific but I just noticed these things occurring. Currently I take two in the morning with Vitamin C.
I have personally been looking into natural choices for my health. My goal has been to repair and restore versus patch and band aid. To find that MSM is working at the cellular level is huge to me. I have learned that taking supplements, herbs, using essential oils, etc. does not work like a medication. Patience is the key. It is working from the inside out. The purpose is to help your body to return to a level that allows your body to do what it was created to do - HEAL ITSELF. Also consistency is a key. If you do not take them consistently/correctly then you can't expect good results.
Just a mention, I am currently, due to the MSM booklet I read looking at the NAC supplement to take as well. I see that Doctor's Best carries that one and will likely add this to my daily as well.
I've ordered it in the passed and will continue to do so.
After just two days of using Doctor's Best MSM, my knee is back to to its normal state. I can walk, stand, cook, and am no longer terrified of simply moving around.
I know that everyone reacts differently to meds and understand that each person's experiences will be different, but this works for me. Right now I'm very happy with my results.
Top reviews from other countries
Reviewed in Singapore on September 23, 2023
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