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Doctor's Best MSM with OptiMSM, Joint Support, Immune System, Antioxidant and Protein-Building Role, Non-GMO, Gluten Free, 1000 mg, 180 Caps (DRB-00064)

4.6 4.6 out of 5 stars 5,440 ratings

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About this item

  • DOCTOR’S BEST MSM FEATURES OPTIMSM: with OptiMSM a high quality purified MSM (methylsulfonylmethane) backed by numerous clinical studies for safety and efficacy. MSM is a natural sulfur compound that helps support the formation of healthy connective tissues. It also helps support overall joint mobility, and a normal range of motion.
  • BENEFITS TO JOINTS: MSM is a natural sulfur that helps form the antioxidants N-acetylcysteine and glutathione and serves as a key structural nutrient in healthy joints. Improves joint function and helps protect cartilage, mobility, reduces joint pain, increases range of motion.
  • IMMUNE SUPPORT: MSM provides support for immune function, and for the body’s antioxidant and overall protective capacities resulting in a stronger immune response.
  • NATURE’S BEAUTY MINERAL: MSM provides sulfur and is often called “nature’s beauty mineral”. Sulfur restores collagen production that supports healthy skin and is a building block of keratin, an essential protein for improving skin, hair and nails.
  • CLINICAL STUDIES: Sulfur continues to be an important dietary nutrient to support healthy aging. With its regulation of glutathione and other ways in the body, MSM can help support healthy skin, joint mobility, cartilage, and the antioxidant response.
  • During the summer months products may arrive warm but Amazon stores and ships products in accordance with manufacturers' recommendations, when provided.

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From the manufacturer

MSM joint comfort and mobility healthy immune antioxidant defenses
MSM joint comfort and mobility healthy immune antioxidant defenses

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Doctor’s Best MSM with OptiMSM a high quality purified MSM (methylsulfonylmethane) backed by numerous clinical studies for safety and efficacy.*

MSM IS a natural sulfur compound that helps support the formation of healthy connective tissues. It also helps support overall joint mobility, and a normal range of motion.* It also may help reduce oxidative damage to support a immune system.

MSM provides the sulfur reputable for being nature’s ‘beauty mineral’. Sulfur is a key component of collagen that supports the skin’s structural framework and is also a building block of keratin, a structural constituent of hair and nails.*

MSM joint comfort and mobility healthy immune antioxidant defenses

MSM joint comfort and mobility healthy immune antioxidant defenses

MSM joint comfort and mobility healthy immune antioxidant defenses

What are the benefits of MSM?

  • Helps support joint comfort and mobility*
  • Helps support immune response*
  • Helps support antioxidant defenses*
  • Helps support overall for hair, skin, and nails*

Why take MSM?

  • MSM may help form, reinforce, and protect joint tissue throughout the body.*
  • MSM is a natural sulfur that helps form the antioxidants N-acetylcysteine and glutathione and serves as a key structural nutrient in joints.
  • Since MSM enhances keratin, MSM offers additional support hair and nails.*

How does it work?

  • MSM’s supports the disulfide bonds that reinforce collagen fibers, a property that’s believed to promote tissue integrity and resilience.
  • MSM’s may also help promote the maintenance of sound joint structure, ultimately enhancing healthy joint function. In soft tissues, MSM’s collagen support and soothing properties may help promote recovery after exercise.
  • Laboratory research suggests MSM can help regulate free radical production by neutrophils (white blood cells in the body.*

Promotes joint comfort and mobility.*

In a double blind, placebo-controlled trial, 50 men and women were randomized to receive either 3,375 mg (3.375 grams) of MSM or a placebo daily for 12 weeks.7 Participants were instructed to take the tablets (each was 1.125 grams) in three doses per day with food, and to avoid taking the tablets before bed. Several validated and reliable scoring methods were used to measure joint function and comfort during the study. Compared with placebo, MSM was shown to significantly promote joint function and comfort, without side effects.

A larger dose was used in a randomized, double blind, placebo-controlled trial of 50 men and women (ages 40–76).8 Participants were randomized into two groups to receive either placebo capsules or OptiMSM in 1 gram capsules for 12 weeks. They were instructed to ramp up to the eventual dose of 6 grams per day by starting with two doses of 2 grams per day for 3 days, followed by an increase to 4 grams per day for the next 4 days. At the beginning of the second week, the dose was raised to 3 grams twice daily. Participants were instructed to take the MSM with food, and to avoid taking it at bedtime. Knee joint function and comfort were measured by standardized (reliable and valid) questionnaires. After 12 weeks, physical function and knee joint comfort were shown to be superior in the MSM group when compared to placebo.

In a more complex double blind study, MSM was tested versus (a) a placebo, (b) glucosamine, and (c) a combination of MSM with glucosamine, in 118 men and women (ages 40–70).9 Participants were randomized into four groups to receive either a placebo, MSM alone (500 mg three times daily), glucosamine alone (500 mg three times daily), or MSM + glucosamine (500 mg each, three times daily). Using a number of analytical tools that measured joint functionality, comfort, and quality of life related to joint health, the researchers found that the MSM and glucosamine groups experienced significant support for joint health, whereas the placebo group experienced no such benefits. Additionally, the combination of MSM + glucosamine was significantly better at promoting joint comfort and functional ability than either taken alone.

MSM could serve as a source of sulfur to support the maintenance and formation of cartilage, thereby supporting knee joint health.10 Its two methyl groups could be valuable to its actions, being necessary for tissue repair and maintenance. Its molecular structure suggests it could also have redox (electronic catalytic) properties that would facilitate antioxidant or other human benefits.

Enhances antioxidant defenses.*

Supports healthy immune response.*

Oxidative stress is a term used to describe negative imbalance between production of reactive oxygen species (ROS) and the body’s antioxidant capacities. Strenuous exercise have the potential to create an uptick of ROS, and subsequently oxidative stress.11 Human and animal studies suggest that taking MSM prior to exercise may help to ease oxidative stress, especially in individuals not accustomed to the stress of exercise.12, 13.

In an exploratory trial of eight healthy men accustomed to a moderate amount of exercise (no more than 2.5 hours per week), the effect of MSM on antioxidant capacity after exercise was investigated. Half of the participants were given 1.5 grams of OptiMSM per day, and the other half 3.0 grams per day. Both groups took the MSM for 30 days, and were instructed to split their daily dose in order to take half of it in the morning and half in the evening. On two exercise test days (before and after 28 days of MSM consumption), participants took their morning MSM dose immediately prior to eating a standardized breakfast, then performed 18 sets of a standardized exercise. A statistically significant increase in blood antioxidant capacity following exercise was reported in the group taking 3 grams MSM daily, as measured by the well-accepted Trolox Equivalent Antioxidant Capacity assay.12.

MSM has been suggested to support healthy immune function through antioxidant actions. Neutrophils, the most abundant white blood cells in the body, routinely release free radicals crucial to their immune activities; this can be a double-edged sword, as excessive free radical generation contributes to oxidative stress. Laboratory research suggests MSM can help regulate free radical production by neutrophils.14 In mice macrophage (immune) cells, MSM was shown to down-regulate overactive immune factors without being toxic to the cells.15 In a mouse model examining joint health, MSM dissolved in the drinking water influenced immune function in a way that significantly supported joint structure and function when compared to mice in a control group.16.

MSM’s benefits for human immune function were studied in an open-label clinical trial. A total 50 men and women were given OptiMSM, 2.6 grams per day for 30 days.17 The MSM was given as four 650 mg capsules-two in the morning and two in the afternoon-each day. Immune function was measured by questionnaire, which included three subsections of questions about upper respiratory health (the head, eyes, nose, and throat), lower respiratory health (the lungs and chest), and energy level. The data suggested MSM produced clinically significant support for the upper respiratory system after one week, the lower respiratory system after three weeks, and enhanced energy levels after two weeks. These benefits continued into the fourth and final week of the study. A subset of 16 participants who experienced the least benefit from the MSM were selected to continue taking OptiMSM for an additional 14 days, but at the higher dose of 5.2 grams per day. These individuals then reported experiencing significantly enhanced energy levels and superior overall respiratory scores.

While new research is exploring the potential of methylsulfonylmethane in promoting the maintenance of GI health18 and bone health,19 the current clinical evidence shows MSM provides meaningful support for the joints, for immune function, and for the body’s antioxidant and overall protective capacities. MSM is proven very safe to take, very well tolerated, and effective at intakes as high as 6000 mg (6 grams) per day.

Scientific References:

1. Monograph. Altern Med Rev 2003;8:438-41.

2. Parcell S. Altern Med Rev 2002;7:22-44.

3. Lovelock JE, Magga RJ. Nature 1972;237:452-453.

4. Jacob SW, Herschler R. Annals of the NY Acad Sci 1983;411:xiii-xvii.

5. Pearson TW, Dawson HJ, Lackey HB. J Agric Food Chem 1981;29:1089-91.

6. Silva Ferreira AC, Rodrigues P, Hogg T, Guedes De Pinho P. J Agric Food Chem 2003;51:727-32.

7. Debbi EM, Agar G, Fichman G, others. BMC Complement Altern Med 2011;11:50.

8. Kim LS, Axelrod LJ, Howard P, others. Osteoarthritis Cartilage 2006;14:286-94.

9. Usha PR, Naidu MU. Clin Drug Investig 2004;24:353-63.

10. Ezaki J, Hashimoto M, Hosokawa Y, Ishimi Y. J Bone Miner Metab 2013;31:16-25.

11. Fisher-Wellman K, Bloomer RJ. Dyn Med 2009;8:1.

12. Kalman DS, Feldman S, Scheinberg AR, others. J Int Soc Sports Nutr 2012;9:46.

13. Maranon G, Munoz-Escassi B, Manley W, others. Acta Vet Scand 2008;50:45.

14. Beilke MA, Collins-Lech C, Sohnle PG. J Lab Clin Med 1987;110:91-6.

15. Kim YH, Kim DH, Lim H, others. Biol Pharm Bull 2009;32:651-6.

16. Hasegawa T, Ueno S, Kumamoto S, Yoshikai Y. Jpn Pharmacol Ther 2004;32.

17. Barrager E, Veltmann JR, Jr., Schauss AG, Schiller RN. J Altern Complement Med 2002;8:167-73.

18. Amirshahrokhi K, Bohlooli S, Chinifroush MM. Toxicol Appl Pharmacol 2011;253:197-202.

19. Joung YH, Lim EJ, Darvin P, others. PLoS One 2012;7:e47477.

Product Description

Best MSM supplies highly purified MSM (methylsulfonylmethane), a compound notable for its methyl groups (required for numerous metabolic functions) and the conditionally essential mineral sulfur, which is a crucial component of powerful antioxidants such as N-acetylcysteine and glutathione. Although MSM occurs naturally in some foods and in the human body at low concentrations, a significant amount of MSM is lost during the heating and processing of foods.

Product details

  • Is Discontinued By Manufacturer ‏ : ‎ No
  • Product Dimensions ‏ : ‎ 3.13 x 3.13 x 5.19 inches; 10.24 ounces
  • Item model number ‏ : ‎ DRB-00064
  • Date First Available ‏ : ‎ October 2, 2001
  • Manufacturer ‏ : ‎ Doctor’s Best, Inc
  • ASIN ‏ : ‎ B000BD4DI6
  • Country of Origin ‏ : ‎ USA
  • Customer Reviews:
    4.6 4.6 out of 5 stars 5,440 ratings

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Doctor's Best MSM with OptiMSM, Joint Support, Immune System, Antioxidant and Protein-Building Role, Non-GMO, Gluten Free, 1000 mg, 180 Caps (DRB-00064)
Doctor's Best MSM with OptiMSM, Joint Support, Immune System, Antioxidant and Protein-Building Role, Non-GMO, Gluten Free, 1000 mg, 180 Caps (DRB-00064)
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Price$13.28-15% $13.73
List:$16.15
$22.99-19% $16.99
List:$20.95
$49.87$17.95
Price Per Unit$0.07 / Count$0.05 / Count$0.08 / Count$0.08 / Count$0.17 / Count$0.07 / Count
Delivery
Get it as soon as Sunday, Mar 31
Get it as soon as Sunday, Mar 31
Get it as soon as Sunday, Mar 31
Get it as soon as Sunday, Mar 31
Get it as soon as Sunday, Mar 31
Customer Ratings
Easy to swallow
4.3
4.6
3.1
4.1
4.4
3.2
Pain relief
4.2
4.5
3.8
4.5
3.5
Flavor
4.5
4.6
4.0
3.5
Range of motion
4.2
2.3
4.1
Sold By
Amazon.com
Carlyle
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Amazon.com
Swanson Health Products
eSupplements
keyword type
msm-nutritional-supplements
msm-nutritional-supplements
msm-nutritional-supplements
msm-nutritional-supplements
coenzyme-q10-nutritional-supplements
multiple-vitamin-mineral-combinations
form
Capsule
Capsule
Caplet
Capsule
Softgel
Tablet
size
180C
250 Count (Pack of 1)
300 Count (Pack of 1)
200 Count (Pack of 1)
100 Count (Pack of 3)
240 Count (Pack of 1)
weight
0.64 pounds
7.42 ounces
0.69 kilograms
0.29 kilograms
0.18 pounds
0.41 kilograms
age range
Adult
Adult
Adult
Adult
Adult
Adult
product benefit
Bone & Joint Support
Antioxidant
Antioxidant
serving suggestion
3 capsules
2 capsule
2 caplets
1 capsule
One Softgel
2 tablets daily with water

Important information

Safety Information

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.This product is labelled to United States standards and may differ from similar products sold elsewhere in its ingredients, labeling and allergen warnings

Ingredients

Methylsulfonylmethane 1 gram (1000 mg) , Gelatin (capsule)

Directions

Take 1 capsule twice daily, with or without food, or as recommended by a nutritionally-informed physician.

Legal Disclaimer

These statements have not been evaluated by the Food & Drug Administration. This products is not intended to diagnose, cure, mitigate, treat, or prevent any disease.

Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Looking for specific info?

Customer reviews

4.6 out of 5 stars
4.6 out of 5
5,440 global ratings

Customers say

Customers like the quality, side effects, ease of swallowing, pain relief, and effect on skin and hair of the nutritional supplement. For example, they mention it's a great product, helps you detox your body from heavy metals, and that it'll improve your skin, hair, and nails.

AI-generated from the text of customer reviews

149 customers mention135 positive14 negative

Customers have good things to say about the pain relief provided by the MSM supplement. They say, for example, it helps to reduce knee and lower back pain, cramps, and muscle pulls. Customers also say it's effective for polymyalgia rheumatica pain and stiffness, and helps to relieve chronic pain. They also say that it helps strengthen the blood vessels and rid the body of toxins. Customers say it completely cures their trigger fingers.

"...have noticed happening with me: Within the first week I noticed a lift in my mood. I also noticed that I began sleeping better at night...." Read more

"...My nails and hair are growing stronger, faster...." Read more

"...My hair is also growing faster - noticeably...." Read more

"...I have scoliosis in mid back and sit/work all day. It keeps the pain away. Powdered capsules easy to swallow." Read more

109 customers mention109 positive0 negative

Customers are satisfied with the quality of the msm supplement. They mention it's a great product, high quality, and pure. Some say that the product has few side effects and is well tolerated.

"...A very enlightening and promising read.I did a little research on the internet to find a quality MSM product...." Read more

"...I sleep so much better. It is pure MSM and I can definitely tell the difference between this and other brands...." Read more

"...Great product!" Read more

"I like the fact that this is pure MSM, with no fillers or flow agents.I also like the fact that the capsule is gelatin...." Read more

71 customers mention62 positive9 negative

Customers like the performance of the nutritional supplement. For example, they say it works well, has amazing results, and starts working almost immediately. Some mention that it helps tremendously and that it works at the cellular level.

"...To find that MSM is working at the cellular level is huge to me. I have learned that taking supplements, herbs, using essential oils, etc...." Read more

"...My neck pops with every breath I take. These have helped tremendously by giving me the ability to turn my head while driving and I no longer wake up..." Read more

"...took the MSM I felt like I had taken a pain medication - I could actually feel it working!..." Read more

"Value is great and seems to work!" Read more

67 customers mention67 positive0 negative

Customers find the nutritional supplement easy to swallow and easy on their budget. They say it provides good value and quality for money. Customers also mention that the amount of caplets and the price drew them to buy this brand.

"...Doctor's Best turned up in the top 2 products. Turns out it is reasonably priced. Yea! I have been taking this product for a month now...." Read more

"...It comes at a great price for the amount you receive. I have more energy...." Read more

"Best pricing for a quantity of MSM. Doctor's Best does not subscribe to third party verification for their products as far as I can tell...." Read more

"Value is great and seems to work!" Read more

23 customers mention23 positive0 negative

Customers say the nutritional supplement improves their skin, hair, and nails. They say it helps to maintain a smoother complexion, looks more plump, and youthful, and is amazing for hair and skin. Customers also experience improved joint health and skin, all without any unwanted side effects. They also mention that the product helps clear their acne up.

"...also noticed (and other people have commented) that my skin looks more plump and youthful. My nails and hair are growing stronger, faster...." Read more

"...I've experienced improved joint health and skin, all without any unwanted side effects. A win-win for those looking for natural remedies." Read more

"The supplement is made for "Joint Support, Immune System, & Antioxidant"...." Read more

"MSM is great for releasing toxins, which helps with allergies, joint pain, skin and hair health. I've been using this for years...." Read more

19 customers mention19 positive0 negative

Customers find the capsules easy to swallow. They also say the pills are easy to use and have experienced no side effects.

"...It keeps the pain away. Powdered capsules easy to swallow." Read more

"I’m on bottle two with my family! They are easy to take and are tasteless! Love the fact they have no smell!" Read more

"Easy to take." Read more

"...Easy to swallow and your joints an body will thank you for it." Read more

12 customers mention9 positive3 negative

Customers like the side effects of the nutritional supplement. They say it helps detox your body from heavy metals, provides sulfur which plays a critical role in detoxification, and helps with allergies, joint pain, and skin. Customers also say it's an antioxidant and doesn't cause weight gain.

"I've been taking MSM supplements, and the best part is they didn't cause any weight gain!..." Read more

"The supplement is made for "Joint Support, Immune System, & Antioxidant"...." Read more

"...However, day 3 was the beginning of multiple undesired side effects including most notably headaches & fatigue...." Read more

"MSM is great for releasing toxins, which helps with allergies, joint pain, skin and hair health. I've been using this for years...." Read more

10 customers mention7 positive3 negative

Customers like the size of the nutritional supplement. They say it's fairly compact, making it easy to swallow. Some customers also mention that the capsules are very large.

"...It's now been 3 months and my hair feels BIG - and I've never had big hair, ever...." Read more

"...These are very large capsules like most in this category but 3 per day?..." Read more

"When capsule power is poured into a glass of water there are various sized white balls which do not dissolve...." Read more

"...This particular product is in smaller size capsule so it is easier to swallow than other brands." Read more

Best companion for serrapeptase enzyme
5 Stars
Best companion for serrapeptase enzyme
This product is amazing considering how basic functions depends on it.I bought this to aid the enzyme called serrapeptase to eat away an adhesion on the muscle and nerve located on the piriformis muscle, which produced a lot of pain and movement restrictions.Based on my observation this MSM helped a lot the process taken by the serrapeptase and may I add with very desirable side effects such as better skin quality, hair thickness and better digestive experience overall.I would definitely recommend this product to anyone who needs an aid in their metabolic system and process, or anyone working with proteolytic enzymes.
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Top reviews from the United States

Reviewed in the United States on September 15, 2017
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Reviewed in the United States on July 11, 2023
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Reviewed in the United States on January 3, 2024
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Top reviews from other countries

Shambhavi Rajiva
5.0 out of 5 stars Awesome product
Reviewed in India on August 21, 2019
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NohH
5.0 out of 5 stars Delighted
Reviewed in Singapore on September 23, 2023
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NohH
5.0 out of 5 stars Delighted
Reviewed in Singapore on September 23, 2023
Good stuff. Received on good condition.
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neha
5.0 out of 5 stars Recommended for all
Reviewed in India on April 11, 2018
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Amazon Customer
4.0 out of 5 stars Good sevice & nice product
Reviewed in India on December 18, 2016
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