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FRONTLINE Plus Flea and Tick Treatment for Medium Dogs Up to 23 to 44 lbs, 3 Treatments

4.4 4.4 out of 5 stars 20,957 ratings
Amazon's Choice highlights highly rated, well-priced products available to ship immediately.
Amazon's Choice in Dog Flea Drops by Frontline

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About this item

  • Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease.
  • Break the flea life cycle with FRONTLINE Plus. Specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control.
  • Trusted by pet owners for over 20 years**, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days.
  • FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products.
  • Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations.
  • Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus.

Customer ratings by feature

Easy to use
4.0 4.0
Easy to remove
3.5 3.5
Scent
3.5 3.5
Value for money
3.1 3.1

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FRONTLINE Plus Flea and Tick Treatment for Medium Dogs Up to 23 to 44 lbs, 3 Treatments
FRONTLINE Plus Flea and Tick Treatment for Medium Dogs Up to 23 to 44 lbs, 3 Treatments
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PetArmor Plus Flea and Tick Prevention for Dogs, Dog Flea and Tick Treatment, 12 Doses, Waterproof Topical, Fast Acting, Medium Dogs (23-44 lbs)
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Price-18% $40.99
List:$49.99
$94.99$20.96$46.98-13% $54.99
List:$62.99
$79.96
Delivery
Get it as soon as Sunday, Mar 31
Get it as soon as Sunday, Mar 31
Get it as soon as Sunday, Mar 31
Get it as soon as Sunday, Mar 31
Get it as soon as Sunday, Mar 31
Get it as soon as Sunday, Mar 31
Customer Ratings
Easy to use
4.0
4.0
4.2
4.4
4.0
Scent
3.5
3.6
3.3
4.4
3.4
Value for money
3.1
3.0
3.1
3.8
3.0
Flavor
1.9
3.4
2.6
2.4
Sold By
Amazon.com
Amazon.com
Amazon.com
Amazon.com
Amazon.com
Amazon.com
target audience
Dog
Adult
Dog
Adult
age range
All Life Stages
All Life Stages
8 weeks or older
All Life Stages
All Life Stages
All Life Stages
scent
Unscented
No Scent
Topical
No Scent
No Scent
form
Stick
Drops
Stick
Stick
Oil
volume
0.14 fluid ounces
4.02 milliliters
18 milliliters
8.04 milliliters
active ingredients
fipronil and (S)-methoprene
Fipronil, (S)-methoprene, Pyriproxyfen
Fipronil
Fipronil, Permethrin, Pyriproxyfen
Fipronil, (S)-methoprene, Pyriproxyfen
Methoprene, Fipronil
weight
1 ounces
0.2 pounds
0.08 pounds
0.13 pounds

From the brand


From the manufacturer

Smiling man playing fetch outside with healthy dog. Frontline Plus awarded Newsweek most trusted
Frontline Plus has been trusted by pet owners for over 20 years and kills fleas and chewing lice
Answers to frequently asked questions about Frontline flea and tick prevention and treatment plans

How to Apply FRONTLINE Plus for Dogs

Step one woman reading instructions on pack before applying flea and tick non prescription treatment

Step two woman holding applicator upright and away from her face before opening by snapping off tip

Step three prep dog for flea treatment application by using fingers to part fur so skin is visible

Step four place the open applicator to dogs skin and squeeze out all contents on dog

Read full instructions on packaging before use. Shown here: Size Large 45-88 lbs.

Use scissors to separate one blister. Hold applicator upright with foil side toward you and snap applicator tip off.

Part dog’s hair between shoulder blades until skin is visible.

Place applicator tip directly against exposed skin and apply entire contents directly to the skin. Do not apply on top of hair.

Pack of Frontline Plus for small dog breeds tratamiento de pulgas y garrapatas para perros pequenos Pack of Frontline Plus for medium dog breeds medicina para matar pulgas y garrapatas Pack of Frontline Plus for large dog breeds prevención de pulgas y garrapatas para perros grandes Pack of Frontline Plus for xl dog breeds control de pulgas y garrapatas para perros extra grandes Frontline Plus Cat
FRONTLINE Plus for Small Dogs FRONTLINE Plus for Medium Dogs FRONTLINE Plus for Large Dogs FRONTLINE Plus for X-Large Dogs FRONTLINE Plus for Cats
Customer Reviews
4.4 out of 5 stars
43,549
4.4 out of 5 stars
20,957
4.5 out of 5 stars
13,629
4.6 out of 5 stars
3,617
4.4 out of 5 stars
43,333
Recommended pet size 5 to 22 pounds 23 to 44 pounds 45 to 88 pounds 89 to 132 pounds Cats and kittens over 1.5 pounds
Kills adult fleas, flea eggs, and flea larvae
Kills ticks and chewing lice
Minimum age of pet for use Dogs and puppies 8 weeks and older Dogs and puppies 8 weeks and older Dogs and puppies 8 weeks and older Dogs and puppies 8 weeks and older Cats and kittens 8 weeks and older
Available sizes 3, 6 and 8-Dose 3, 6 and 8-Dose 3, 6 and 8-Dose 3, 6 and 8-Dose 3, 6 and 8-Dose
Do not use on cats Do not use on cats Do not use on cats Do not use on cats For use on cats only

Product guides and documents

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Product details

  • Is Discontinued By Manufacturer ‏ : ‎ No
  • Product Dimensions ‏ : ‎ 5.75 x 0.75 x 4.5 inches; 1 ounces
  • Item model number ‏ : ‎ P004FLTSP-23-44
  • Department ‏ : ‎ Pet Supplies
  • Date First Available ‏ : ‎ October 2, 2001
  • Manufacturer ‏ : ‎ Boehringer Ingelheim Animal Health
  • ASIN ‏ : ‎ B0002J1FN0
  • Country of Origin ‏ : ‎ Germany
  • Customer Reviews:
    4.4 4.4 out of 5 stars 20,957 ratings

Product Description

Keep your dog protected with the #1 name in flea & tick protection*, FRONTLINE®. FRONTLINE Plus for Dogs is a fast-acting, long-lasting waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease. Break the flea life cycle — FRONTLINE Plus for Dogs is specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control. Trusted by pet owners for over 20 years**— FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply. Applied to a single point on your pet, the flea and tick control treatment covers your dog's entire body and deposits in the sebaceous glands. These glands act as a reservoir, continuously replenishing the treatment onto your pet, working even if your dog gets wet. Just one dose of FRONTLINE Plus each month protects against fleas & ticks for a full 30 days. FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products. Appropriately treat all pets in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations. Subscribe and save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus. Be sure to visit our brand store and follow us to stay up to date on new FRONTLINE products, features, tips and more. References: *Data on file at Boehringer Ingelheim. **Data showing 20 years of trust in killing fleas and ticks is on file at Boehringer Ingelheim.

FRONTLINE® Plus for Dogs spreads from the single point of application, rapidly covering the entire dog and localizing in the hair, on the surface of the skin, and in the sebaceous glands. These glands act as a reservoir, continuously replenishing FRONTLINE Plus for Dogs onto the skin and hair coat, so it keeps working even if the dog gets wet.**Your pet needs to be dry at the time FRONTLINE Plus is applied and remain dry 24 hours after application.

Important information

Safety Information

KEEP OUT OF REACH OF CHILDREN. WARNING: PRECAUTIONARY STATEMENTS - HAZARDS TO HUMANS: WARNING. Causes substantial but temporary eye injury. Do not get in eyes or on clothing. Avoid Contact with skin. Harmful if swallowed. Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco or using the toilet. Remove and wash clothing that may have come in contact with the product before reuse. HAZARDS TO DOMESTIC ANIMALS: For external use on dogs ONLY. Do not use on animals other than dogs. Do not use on dogs under 9 weeks of age or weighing less than 5 lbs. Individual sensitivities may occur after using ANY pesticide product. Dogs may experience some temporary irritation at the site of product application. If signs of sensitivity occur, bathe your dog with mild soap or shampoo and rinse with large amounts of water. If signs of sensitivity occur and persist, contact a veterinarian immediately. If your dog has an unusual reaction to the initial application, consult a veterinarian before repeating application. Certain medications can interact with pesticides. Consult a veterinarian before using on medicated, debilitated, aged, pregnant or nursing dogs, or dogs known to be sensitive to pesticide products. Consult a veterinarian for guidance on use against Sarcoptes mites. This product is not a substitute for a prescribed heartworm preventative.nCall 1-888-637-4251, for assistance. PHYSICAL OR CHEMICAL HAZARDS: Do not allow this product to come in contact with an oxidizing agent, as a hazardous chemical reaction may occur Harmful if swallowed. Causes substantial but temporary eye injury. Do not get in eyes or on clothing. Avoid contact with skin. Wear (specify appropriate protective eyewear such as goggles, face shield, or safety glasses). Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco or using the toilet. Remove and wash contaminated clothing before reuse.

Ingredients

Fipronil (9.8%)|(S)-Methoprene (8.8%)

Directions

Directions for Use Step 1. To REMOVE Applicator: 1. Use scissors to separate one blister; 2. Use scissors to cut along dotted line; 3. Peel down foil to remove the applicator. Step 2. OPEN Applicator. Hold upright with foil side toward you and snap applicator tip. Step 3. APPLY FRONTLINE Plus. Part the dog’s hair between the shoulder blades. Place the applicator tip just above the skin and squeeze. Apply entire contents of the applicator in a single spot directly onto the dog’s skin. Do not apply on top of the hair coat. Avoid contact with treated area until dry. Do not allow your dog to ingest the product. Do not apply to dogs weighing less than 23 lbs. or younger than 8 weeks of age. Do not use more than one application per dog per month. Frequency Use monthly to control fleas and ticks. Do not reapply FRONTLINE Plus for 30 days.

Legal Disclaimer

Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product.

Customer reviews

4.4 out of 5 stars
4.4 out of 5
20,957 global ratings

Customers say

Customers like the ease of use, quality and value of the pet pest control product. For example, they mention it's easy to apply, the instructions are clear and it saves money. Some appreciate ticks. Opinions are mixed on fleas, side effects, and performance.

AI-generated from the text of customer reviews

413 customers mention305 positive108 negative

Customers like the value of the pet pest control product. They say it saves them money as they don't have to buy 2 different boxes.

"...Easy to apply on my dog. Price is right too." Read more

"...Yay! Second dogs bath is tomorrow. Great product and it’s worth the extra money!" Read more

"...It’s a little pricey, but my dogs health is invaluable." Read more

"Worth every penny. Tried spraying, flea baths, and then I finally decided to go with frontline...." Read more

316 customers mention266 positive50 negative

Customers like the quality of the pet pest control product. They say it is reliable, fine, and has a good reputation. Some customers also mention that the medicine is high quality. Overall, most are satisfied with the product's quality and effectiveness.

"The product is very good although a little strong for the recommended dose!..." Read more

"For what it is, this is a fine product...." Read more

"...For safety, Frontline Plus can't be beat! It's even safe to use on pregnant and lactating dogs...." Read more

"Great product and great service" Read more

119 customers mention112 positive7 negative

Customers find the pet pest control product easy to use. They mention that the instructions are clear and easy to understand. They also appreciate the clear plastic vials and the fact that the product is trouble free.

"I love that I can order and receive package from my home. Easy to apply on my dog. Price is right too." Read more

"This product was recommended by my daughters vet. The application is easy, just put some drops on the dogs back by the neck and by the butt, that's..." Read more

"...In those instances this works just fine. It easy to use and last for 1 month. My dog has never had any infestations while using it" Read more

"Easy to use. Help with fleas for a month. I didn’t see my dog scratching when i used it." Read more

95 customers mention70 positive25 negative

Customers like the ticks. They say the product is effective against ticks and has been used for years. They also say it prevents more ticks from latching on.

"We tried less expensive options, but this works best at deterring ticks." Read more

"No fleas, no ticks !! I have a heavy coated collie on cape cod which is tick city and this year was extra bad ….. I got ticks my dog had none" Read more

"...A week after applying they were covered in ticks, and 2 weeks after that I keep finding them on them still. Very disappointed." Read more

"...And I like knowing that Frontline can kill the tick on contact with his skin / fur rather than having to wait for it to bite him...." Read more

914 customers mention412 positive502 negative

Customers are mixed about the performance of the pet pest control. Some mention it works very well, while others say it's ineffective and a complete waste of money.

"...I apply it about every 3 weeks. I'm convinced it does very little to nothing to kill or repell fleas...." Read more

"...had an issue with any of my dogs with fleas or ticks, the product clearly works well...." Read more

"...But it gas not been as effective as advertised. Probably not suited for the tropical climate I'm in." Read more

"...dose because my dog ​​feels a little bad about it, but it works perfectly!" Read more

456 customers mention261 positive195 negative

Customers are mixed about the fleas. Some mention that they use Frontline and never have any issue with flea. They say it helps keep the flees and ticks off of their dogs. However, others say that they still have flea and tiny ticks after using the product for two months.

"works good for fleas" Read more

"Used this twice and as of today, she still has fleas!I’m afraid to put any more on her, it hasn’t even been a month , it’s too dangerous...." Read more

"...My dog is free of live fleas, he still has some larvae but I think those are dying off because i still don’t see any babies when I check here and..." Read more

"...Its now 9 days post application and she still has fleas and tiny ticks...." Read more

109 customers mention72 positive37 negative

Customers are mixed about the side effects of the pet pest control. Some mention that it doesn't make their skin irritate, while others say that it makes them itch like crazy.

"Frontline is by far the best preventative and reactive flea treatment I've used outside of a prescription...." Read more

"...There have been no adverse effects on the animals either. We also see no sign of fleas remaining on the dogs at all...." Read more

"...BUT fibronil is toxic to cats . . . so you need to be careful you don't kill your neighbor's outdoor cat . . . or any strays . . ...." Read more

"...There are no adverse effects either. I tried another brand one time and it stank so bad I'd get headaches...." Read more

43 customers mention14 positive29 negative

Customers are mixed about the durability of the pet pest control product. Some mention it lasts all month, while others say it wears out a bit near the end of the month. That said, some say it does not stop the tick life cycle and that it permanently damages both fabric and leather.

"...This used to be the best thing but now it seems like I'm lucky if it lasts 3 weeks...." Read more

"...in less than 30 days they came back in about 10 days so this product doesn't last there are other oral substitutions that I'm going to have to try." Read more

"I like the fact that you can administer it on a monthly basis" Read more

"...I've noticed that in the middle of summer, Frontline plus seems to wear out a bit near the end of the monthly cycle, so I recommend going every..." Read more

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I love that I can order and receive package from my home. Easy to apply on my dog. Price is right too.
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